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KMID : 1188320220160020269
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Gut and Liver
2022 Volume.16 No. 2 p.269 ~ p.276
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Osteoporosis Is Associated with an Increased Risk of Colorectal Adenoma and High-Risk Adenoma: A Retrospective, Multicenter, Cross-Sectional, Case-Control Study
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Nam Ji-Hyung
Koh Myung
Kang Hyoun-Woo
Ryu Kum-Hei
Lee Dong-Seok
Kim Su-Hwan
Jang Dong-Kee
Jeong Ji-Bong
Kim Ji-Won
Lee Kook-Lae
Oh Dong-Jun
Lim Yun-Jeong
Koh Seong-Joon
Im Jong-Pil
Kim Joo-Sung
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Abstract
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Background/Aims: The protective effects of vitamin D and calcium on colorectal neoplasms are known. Bone mineral density (BMD) may be a reliable biomarker that reflects the long-term anticancer effect of vitamin D and calcium. This study aimed to evaluate the association between BMD and colorectal adenomas including high-risk adenoma.
Methods: A multicenter, cross-sectional, case-control study was conducted among participants with average risk of colorectal cancer who underwent BMD and screening colonoscopy between 2015 and 2019. The main outcome was the detection of colorectal neoplasms. The variable under consideration was low BMD (osteopenia/osteoporosis). The logistic regression model included baseline demographics, components of metabolic syndrome, fatty liver disease status, and aspirin and multivitamin use.
Results: A total of 2,109 subjects were enrolled. The mean age was 52.1±10.8 years and 42.6% were male. The adenoma detection rate was 43%. Colorectal adenoma and high-risk adenoma were both more prevalent in subjects with low BMD than those with normal BMD (48.2% vs 38.8% and 12.1% vs 9.1%). In the univariate analysis, old age, male sex, smoking, metabolic components, fatty liver, and osteoporosis were significantly associated with the risk of adenoma and high-risk adenoma. In the multivariate analysis, osteoporosis was independently associated with risk of colorectal adenoma (odds ratio [OR], 1.65; 95% confidence interval [CI], 1.11 to 2.46; p=0.014) and high-risk adenoma (OR, 1.94; 95% CI, 1.14 to 3.29; p=0.014).
Conclusions: Osteoporosis is an independent risk factor of colorectal adenoma and high-risk adenoma.
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KEYWORD
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Bone mineral density, Osteoporosis, Colorectal adenoma, High-risk adenoma
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